Journal article
Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®
D Seidel, A Meißner, M Lackner, E Piepenbrock, J Salmanton-García, M Stecher, S Mellinghoff, A Hamprecht, L Durán Graeff, P Köhler, MP Cheng, J Denis, I Chedotal, J Chander, DL Pakstis, I Los-Arcos, M Slavin, MT Montagna, G Caggiano, M Mares Show all
Critical Reviews in Microbiology | TAYLOR & FRANCIS LTD | Published : 2019
Abstract
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up to 90% underline the need for comprehensive diagnostic workup and even more for new, effective antifungal drugs to improve patient outcome. For a comprehensive analysis, we identified cases of severe Scedosporium spp. and L. prolificans infections from the literature diagnosed in 2000 or later and the FungiScope® registry. For 208 Scedosporium spp. inf..
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