Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: a review
Fabian Yuh Shiong Kong, Patrick Horner, Magnus Unemo, Jane S Hocking
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2019
Rates of bacterial sexually transmitted infections (STIs) continue to rise, demanding treatments to be highly effective. However, curing infections faces significant challenges due to antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma genitalium and especially treating STIs at extragenital sites, particularly rectal chlamydia and oropharyngeal gonorrhoea. As no new antimicrobials are entering the market, clinicians must optimize the currently available treatments, but robust data are lacking on how the properties or pharmacokinetics of antimicrobials can be used to inform STI treatment regimens to improve treatment outcomes. This paper provides a detailed overview of the publis..View full abstract
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P. H. was funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Evaluation of Interventions at Bristol University in partnership with Public Health England (PHE). J. S. H. is supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship.