Evolution of Daptomycin Resistance in Coagulase-Negative Staphylococci Involves Mutations of the Essential Two-Component Regulator WalKR
Jhih-Hang Jiang, Carina Dexter, David R Cameron, Ian R Monk, Sarah L Baines, Iain J Abbott, Denis W Spelman, Xenia Kostoulias, Cara Nethercott, Benjamin P Howden, Anton Y Peleg
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2019
Coagulase-negative staphylococci (CoNS) represent one of the major causes of health care- and medical device-associated infections. Emerging antimicrobial resistance has complicated the treatment of systemic infections caused by CoNS. Here, we describe the prevalence of antimicrobial resistance in clinical CoNS strains from a tertiary care hospital over a 4-year period, and we observed a significant increase in resistance to daptomycin. Notably, Staphylococcus capitis accounted for the majority of these daptomycin-resistant (DAP-R) CoNS. To further investigate the mechanisms of daptomycin resistance in CoNS, daptomycin-susceptible clinical strains of S. capitis and Staphylococcus epidermidis..View full abstract
Awarded by Australian National Health and Medical Research Council
A.Y.P was funded by an Australian National Health and Medical Research Council Practitioner Fellowship (APP1117940) and project grants (APP1047918 and APP1144303).