Journal article

Evolution of Daptomycin Resistance in Coagulase-Negative Staphylococci Involves Mutations of the Essential Two-Component Regulator WalKR

Jhih-Hang Jiang, Carina Dexter, David R Cameron, Ian R Monk, Sarah L Baines, Iain J Abbott, Denis W Spelman, Xenia Kostoulias, Cara Nethercott, Benjamin P Howden, Anton Y Peleg

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2019


Coagulase-negative staphylococci (CoNS) represent one of the major causes of health care- and medical device-associated infections. Emerging antimicrobial resistance has complicated the treatment of systemic infections caused by CoNS. Here, we describe the prevalence of antimicrobial resistance in clinical CoNS strains from a tertiary care hospital over a 4-year period, and we observed a significant increase in resistance to daptomycin. Notably, Staphylococcus capitis accounted for the majority of these daptomycin-resistant (DAP-R) CoNS. To further investigate the mechanisms of daptomycin resistance in CoNS, daptomycin-susceptible clinical strains of S. capitis and Staphylococcus epidermidis..

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