Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines
Yvonne G van der Zwan, Martin A Rijlaarsdam, Fernando J Rossello, Amanda J Notini, Suzan de Boer, D Neil Watkins, Ad JM Gillis, Lambert CJ Dorssers, Stefan J White, Leendert HJ Looijenga
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
BACKGROUND: Originating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS). During physiological germ cell formation/maturation, epigenetic processes guard homeostasis by regulating the accessibility of the DNA to facilitate transcription. Epigenetic deregulation through genetic and environmental parameters (i.e. genvironment) could disrupt embryonic germ cell development, resulting in delayed or blocked maturation. This potentially facilitates the formation of CIS and progression to invasive GCC. Therefore, determining the..View full abstract
This work is supported by funding from the European Society for Pediatric Endocrinology Research Fellowship (YZ). MR is supported by a Translational Grant, Erasmus MC. SB is supported by APA and IPRS scholarships from Monash University. This work was supported by funding from Monash University (SW). MIMR receives support from the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.