Journal article

Role of epigenetics in the etiology of germ cell cancer

Yvonne G Van der Zwan, Hans Stoop, Fernando Rossello, Stefan J White, Leendert HJ Looijenga

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | UNIV BASQUE COUNTRY UPV-EHU PRESS | Published : 2013

Abstract

Embryonic development is strictly controlled by functionality of genes in which the existing networks can act both on transcription and translation regulation. Germ cell cancers (GCC) are unique because of a number of characteristics. In spite of their clinical presentation, i.e., predominantly after puberty, they arise from primordial germ cells/gonocytes that have failed appropriate maturation to either pre-spermatogonia or oogonia. GCC mimic embryonal development to a certain extent, including capacity for totipotency. This knowledge has allowed the identification of informative diagnostic markers, including OCT3/4 (POU5F1), SOX2 and SOX17. An additional marker is the overall demethylated..

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University of Melbourne Researchers