Role of epigenetics in the etiology of germ cell cancer
Yvonne G Van der Zwan, Hans Stoop, Fernando Rossello, Stefan J White, Leendert HJ Looijenga
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | UNIV BASQUE COUNTRY UPV-EHU PRESS | Published : 2013
Embryonic development is strictly controlled by functionality of genes in which the existing networks can act both on transcription and translation regulation. Germ cell cancers (GCC) are unique because of a number of characteristics. In spite of their clinical presentation, i.e., predominantly after puberty, they arise from primordial germ cells/gonocytes that have failed appropriate maturation to either pre-spermatogonia or oogonia. GCC mimic embryonal development to a certain extent, including capacity for totipotency. This knowledge has allowed the identification of informative diagnostic markers, including OCT3/4 (POU5F1), SOX2 and SOX17. An additional marker is the overall demethylated..View full abstract
This work is supported by funding from the European Society for Pediatric Endocrinology Research Fellowship (YZ), Monash University (SW) and the Victorian Government's Operational Infrastructure Support Program (SW, FR).