Journal article

A molecular mechanism for salt stress-induced microtubule array formation in Arabidopsis

Christopher Kesten, Arndt Wallmann, René Schneider, Heather McFarlane, Anne Diehl, Ghazanfar Abbas Khan, Barth-Jan van Rossum, Edwin Lampugnani, Nils Cremer, Peter Schmieder, Kristina Ford, Florian Seiter, Joshua Heazlewood, Clara Sanchez-Rodriguez, Hartmut Oschkinat, Staffan Persson

Published : 2018

Abstract

Abstract Microtubules are filamentous structures necessary for cell division, motility and morphology, with dynamics critically regulated by microtubule-associated proteins (MAPs). We outline the molecular mechanism by which the MAP, COMPANION OF CELLULOSE SYNTHASE1 (CC1), controls microtubule bundling and dynamics to sustain plant growth under salt stress. CC1 contains an intrinsically disordered N-terminus that links microtubules at evenly distributed distances through four conserved hydrophobic regions. NMR analyses revealed that two neighboring residues in the first hydrophobic binding motif are crucial for the microtubule interaction, which we confirmed through live cell analyses. The m..

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