Journal article
Creatinine-based estimation of glomerular filtration rate in patients with a Fontan circulation
TG Wilson, Y d’Udekem, DS Winlaw, RL Cordina, J Ayer, TL Gentles, RG Weintraub, LE Grigg, M Cheung, TM Cain, P Rao, C Verrall, KD Plessis, K Rice, AJ Iyengar
Congenital Heart Disease | TECH SCIENCE PRESS | Published : 2019
DOI: 10.1111/chd.12746
Abstract
Background: Patients with a Fontan circulation are at risk of renal dysfunction. We analyzed cross-sectional data in pediatric and adult Fontan patients in order to assess the accuracy of commonly used serum creatinine-based methods in estimating glomerular filtration rate (GFR). Methods: A total of 124 Fontan patients (58 children, 66 adults) were enrolled across three study centers. Measurement of GFR (mGFR) using in vivo 99mTc-DTPA clearance was performed. Various serum creatinine-based equations were used to calculate estimated GFR (eGFR). Results: Mean mGFR was 108 ± 28 mL/min/1.73 m2 in children and 92 ± 20 mL/min/1.73 m2 in adults. Fourteen children (25%) and 28 adults (45%) had an mG..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
National Health and Medical Research Council, Grant/Award Number: NHMRC Project Grant 1047923