Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers
Nature Communications | NATURE PUBLISHING GROUP | Published : 2019
Awarded by SURF Cooperative
Awarded by Netherlands Organization for Scientific Research (NWO: Netherlands Genomics Initiative (NGI))
Awarded by National Health and Medical Research Council (Australia)
We thank Sjors Kas, Eva Schut, Bastiaan Evers, Ben Morris, Renske de Korte-Grimmerink, Natalie Proost and Rebecca Theeuwsen for providing reagents, technical suggestions, and/or help with the experiments. We are grateful for excellent support from the NKI animal facility, RHPC computing facility, flow cytometry facility, animal pathology facility, transgenic facility, preclinical intervention unit, core facility molecular pathology and biobanking (CFMPB), and genomics core facility. PDX-110 was derived from a primary breast tumor provided by the Victorian Cancer Biobank (supported by the Victorian Government, Australia). This work was carried out on the Dutch national e-infrastructure with the support of SURF Cooperative (e-infra160136). Financial support was provided by the Oncode Institute, the Netherlands Organization for Scientific Research (NWO: Cancer Genomics Netherlands (CGCNL), Cancer Systems Biology Center (CSBC), Netherlands Genomics Initiative (NGI) Zenith 93512009 (J.J.), VICI 91814643 (J.J.)), the European Research Council (ERC Synergy project CombatCancer), a National Roadmap grant for Large-Scale Research Facilities from NWO (J.J.) and National Health and Medical Research Council (Australia) grants 1113133 (J.E.V. and G.J.L.), 1078730 (G.J.L.) and 1102742 (J.E.V.).