Journal article

Review: Biomaterial systems to resolve brain inflammation after traumatic injury

Francesca L MacLean, Malcolm K Horne, Richard J Williams, David R Nisbet

APL BIOENGINEERING | AMER INST PHYSICS | Published : 2018

Abstract

The inflammatory response within the central nervous system (CNS) is a tightly regulated cascade of events which is a balance of both cytotoxic and cytotrophic effects which determine the outcome of an injury. The two effects are inextricably linked, particularly in traumatic brain injury or stroke, where permanent dysfunction is often observed. Chronic brain inflammation is a key barrier to regeneration. This is considered a toxic, growth inhibitory mechanism; yet, the inflammatory response must also be considered as a mechanism that can be exploited as protective and reparative. Repurposing this complex response is the challenge for tissue engineers: to design treatments to repair and rege..

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Grants

Awarded by National Health and Medical Research Council Australia


Awarded by Australian Research Council


Awarded by NHMRC Dementia Research Leadership Fellowship


Funding Acknowledgements

This research was supported by funding from the National Health and Medical Research Council Australia GNT1020332, the Australian Research Council DP130103131. D.R.N. was supported by a NHMRC Dementia Research Leadership Fellowship (GNT1135657). Access to the facilities of the Centre for Advanced Microscopy with funding through the Australian Microscopy and Microanalysis Research Facility is gratefully acknowledged.