Relationships Between Neurofibromatosis-2, Progesterone Receptor Expression, the Use of Exogenous Progesterone, and Risk of Orbitocranial Meningioma in Females
Agus Supartoto, Muhammad Bayu Sasongko, Datu Respatika, Indra Tri Mahayana, Suhardjo Pawiroranu, Hari Kusnanto, Dhimas Hari Sakti, Prima Sugesty Nurlaila, Didik Setyo Heriyanto, Sofia Mubarika Haryana
FRONTIERS IN ONCOLOGY | FRONTIERS MEDIA SA | Published : 2019
Background: The pathogenesis of meningioma in females and its association with exogenous progesterone is remained unclear. This study was aimed to examine expression of Progesterone receptor (PR) and Neurofibromatosis-2 (NF2) and assess their relationships to history of exogenous progesterone use and risk of meningioma. Methods: Our study was a case-control study that involves 115 females, 40 cases who diagnosed with orbito-cranial meningioma and 75 controls of healthy, that has been presented in previous study. The demographic characteristics, reproductive factors, and history of progesterone use were obtained in-depth face-to-face interviews. PR and NF2 mRNA were assessed by real-time quan..View full abstract
This study was funded by University Research Excellence Grant, Ministry of Higher Education and Technology, Government of Indonesia.