Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis

Edward Hill; Alicia M Goodwill; Alexandra Gorelik; Cassandra Szoeke

Journal article

Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis

Edward Hill, Alicia M Goodwill, Alexandra Gorelik, Cassandra Szoeke

NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2019

DOI: 10.1016/j.neurobiolaging.2018.12.008

Abstract

Alzheimer's disease (AD) risk increases with age and lacks efficacious pharmacological options. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers (tau and beta-amyloid) that manifest decades before clinical symptomatology. MEDLINE, PubMed, PsycINFO, Google Scholar, and SCOPUS databases were systematically searched to identify peer-reviewed articles investigating diet and AD biomarkers in the last 2 decades. Two thousand seven hundred twenty-six records were extracted, quality assessed, and double-blind screened by 2 autho..

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University of Melbourne Researchers

Alex Gorelik Author Medicine - Royal Melbourne Hospital

Cassandra Szoeke Author Medicine - Royal Melbourne Hospital

Edward Hill Author Medicine - Royal Melbourne Hospital

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Grants

Awarded by NHMRC, Australia

Awarded by Alzheimer's Association

Funding Acknowledgements

CS is supported by the NHMRC, Australia [grant numbers: 547600, 1032350, and 1062133]. Funding has also been provided from the Alzheimer's Association [grant number NIA320312], the Brain Foundation, and Alzheimer's Association of Australia. EH would like to acknowledge support from the Australian Government Research Training Program Scholarship.