Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry
Simone N De Luca, Luba Sominsky, Alita Soch, Hao Wang, Ilvana Ziko, Michelle M Rank, Sarah J Spencer
BRAIN BEHAVIOR AND IMMUNITY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
Microglia are highly sensitive to dietary influence, becoming activated acutely and long-term by high fat diet. However, their role in regulating satiety and feeding in healthy individuals remains unclear. Here we show that microglia are essential for the normal regulation of satiety and metabolism in rats. Short-term microglial depletion in a Cx3cr1-Dtr rat led to a dramatic weight loss that was largely accounted for by an acute reduction in food intake. This weight loss and anorexia were not likely due to a sickness response since the rats did not display peripheral or central inflammation, withdrawal, anxiety-like behavior, or nausea-associated pica. Hormonal and hypothalamic anatomical c..View full abstract
Awarded by National Health and Medical Research Centre Career Development Fellowship II
This project was supported by funding from a National Health and Medical Research Centre Career Development Fellowship II (APP1128646) to SJS, an RMIT University PhD Scholarship and Publication Grant to SND and an RMIT University Vice Chancellor's Postdoctoral Fellowship to LS.