Journal article

Spastic tail muscles recover from myofiber atrophy and myosin heavy chain transformations in chronic spinal rats

R Luke W Harris, Charles T Putman, Michelle Rank, Leo Sanelli, David J Bennett

JOURNAL OF NEUROPHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2007

Abstract

Without intervention after spinal cord injury (SCI), paralyzed skeletal muscles undergo myofiber atrophy and slow-to-fast myofiber type transformations. We hypothesized that chronic spasticity-associated neuromuscular activity after SCI would promote recovery from such deleterious changes. We examined segmental tail muscles of chronic spinal rats with long-standing tail spasticity (7 mo after sacral spinal cord transection; older chronic spinals), chronic spinal rats that experienced less spasticity early after injury (young chronic spinals), and rats without spasticity after transection and bilateral deafferentation (spinal isolated). These were compared with tail muscles of age-matched nor..

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University of Melbourne Researchers