Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis

AR Martineau; DA Jolliffe; L Greenberg; JF Aloia; P Bergman; G Dubnov-Raz; S Esposito; D Ganmaa; AA Ginde; EC Goodall; CC Grant; W Janssens; ME Jensen; CP Kerley; I Laaksi; S Manaseki-Holland; D Mauger; DR Murdoch; R Neale; JR Rees; S Simpson; I Stelmach; GT Kumar; M Urashima; CA Camargo; CJ Griffiths; RL Hooper

Journal article

Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis

AR Martineau, DA Jolliffe, L Greenberg, JF Aloia, P Bergman, G Dubnov-Raz, S Esposito, D Ganmaa, AA Ginde, EC Goodall, CC Grant, W Janssens, ME Jensen, CP Kerley, I Laaksi, S Manaseki-Holland, D Mauger, DR Murdoch, R Neale, JR Rees Show all

Health Technology Assessment | Published : 2019

DOI: 10.3310/hta23020

Open access

Abstract

Background: Randomised controlled trials (RCTs) exploring the potential of vitamin D to prevent acute respiratory infections have yielded mixed results. Individual participant data (IPD) meta-analysis has the potential to identify factors that may explain this heterogeneity. Objectives: To assess the overall effect of vitamin D supplementation on the risk of acute respiratory infections (ARIs) and to identify factors modifying this effect. Data sources: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, ClinicalTrials.gov and the International Standard Randomised Controlled Trials Number (ISRCTN) registry. Study selection: Randomised, double-blind,..

View full abstract