Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

Grants

Funding Acknowledgements

We thank the patients for their cooperation, Drs. Wendy van Zelst-Stams and Marleen Kets for providing and updating clinical information on the Dutch families, Dr. Alexander Hoischen for assisting in the MIP design, the Genome Technology Platform for MIP sequencing support and Dr. Christian Gilissen for the use of the variant calling and annotation pipeline in the Radboudumc, Nijmegen. We acknowledge the networking support of the COST Actions BM1206 and CA17118. This work was supported by grants from the Dutch Cancer Society (KUN2015-7740), and the Sacha Swarttouw-Hijmans Foundation. R.M.d.V. holds a Fellowship from the Dutch Cancer Society (KWF; KUN2014-6666). A.D. and M.S. hold a grant from the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, on molecular aspects of inherited colorectal carcinoma in Macedonia. C.R.P. holds a grant from Fondo de Investigacion Sanitaria/Plan Estatal de I + D + I 2013-2016/FEDER (PI14/00230). D.D.B. holds a Senior Research Fellowship from the University of Melbourne Research at Melbourne Accelerator Program (R@MAP) and a Fellowship from NHMRC R.D. Wright Career Development. I.P. and D.S. are supported by the Schroeder-Kurth Fund. I.G.C. and P.A.J. are supported by grants from the National Breast Cancer Foundation of Australia and Cancer Australia. L.V. and G.C. hold grants from the Spanish Ministry of Economy and Competitiveness, co-funded by FEDER funds - a way to build Europe (SAF2016-80888-R and SAF2015-68016-R). H.K.S. is supported by the Deutsche Krebshilfe.