Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham; Teresa M MacDonald; Susan P Walker; Natasha Pritchard; Natalie J Hannan; Ping Cannon; Vi Nguyen Tuong; Roxanne Hastie; Stephen Tong; Tu'uhevaha J Kaitu'u-Lino

Journal article

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Vi Nguyen Tuong, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2019

DOI: 10.1038/s41598-018-36645-0

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Abstract

Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and organ injury. GATA2 is a transcription factor expressed in the endothelium which regulates vascular homeostasis by controlling transcription of genes and microRNAs, including endothelial miR126. We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with established early-onset preeclampsia compared to gestation-matched controls (p = 0.002, p < 0.0001, respectively). Using case-control groups selected from a large prospective cohort, whole blood circulating G..

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University of Melbourne Researchers

Tu'uhevaha Lino Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Roxanne Hastie Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Susan Walker Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Natasha Pritchard Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council (NHMRC of Australia)

Awarded by NHMRC

Funding Acknowledgements

We would like to thank the research midwives, Kirsten Dane, Anna Middleton, Gabrielle Pell, Genevieve Christophers and Rachel Murdoch for their contribution to this work. We thank the women at the Mercy Hospital for Women who participated in this research and kindly donated their samples. This work was supported by the National Health and Medical Research Council (NHMRC of Australia (#1065854), Australian Government Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; and the Norman Beischer Medical Research Foundation. S Tong (#1136418), T.J. Kaitu'u-Lino (#1062418) and N.J. Hannan (1146128) were supported by NHMRC Fellowships. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.