Journal article

Pulmonary group 2 innate lymphoid cells: surprises and challenges

Malcolm R Starkey, Andrew NJ McKenzie, Gabrielle T Belz, Philip M Hansbro



Group 2 innate lymphoid cells (ILC2s) are a recently described subset of innate lymphocytes with important immune and homeostatic functions at multiple tissue sites, especially the lung. These cells expand locally after birth and during postnatal lung maturation and are present in the lung and other peripheral organs. They are modified by a variety of processes and mediate inflammatory responses to respiratory pathogens, inhaled allergens and noxious particles. Here, we review the emerging roles of ILC2s in pulmonary homeostasis and discuss recent and surprising advances in our understanding of how hormones, age, neurotransmitters, environmental challenges, and infection influence ILC2s. We ..

View full abstract

University of Melbourne Researchers


Funding Acknowledgements

The authors apologize in advance for and regret any omissions, either unintended or due to space limitations. We acknowledge Guy Cameron and Svenja Loering for their assistance with preparing figures and tables. M.R.S. is supported by an Australian Research Council Discovery Early Career Researcher Award, G.T.B. and P.M.H. are supported by fellowships from the National Health and Medical Research Council (Australia). P.M.H. is also supported by a fellowship from the Faculty of Health, University of Newcastle.