Journal article

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8( ) T cell development

Irina Caminschi, Mireille H Lahoud, Angela Pizzolla, Linda M Wakim

MUCOSAL IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Tissue-resident memory T cells (Trm) in the lung provide a frontline defence against respiratory pathogens. Vaccination models that lodge CD8+ Trm populations in the lung have been developed, all of which incorporate the local delivery of antigen plus adjuvant into the airways; a necessary approach as local cognate antigen recognition is required for optimal lung Trm development. Although pulmonary delivery of antigen is important for lung Trm development, the impact the co-administered adjuvant has on Trm differentiation is unclear. We show that while altering the adjuvant co-administered with the pulmonary delivered antigen does not impact the size of the lung Trm population, a particular ..

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