Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8( ) T cell development
Irina Caminschi, Mireille H Lahoud, Angela Pizzolla, Linda M Wakim
MUCOSAL IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2019
Tissue-resident memory T cells (Trm) in the lung provide a frontline defence against respiratory pathogens. Vaccination models that lodge CD8+ Trm populations in the lung have been developed, all of which incorporate the local delivery of antigen plus adjuvant into the airways; a necessary approach as local cognate antigen recognition is required for optimal lung Trm development. Although pulmonary delivery of antigen is important for lung Trm development, the impact the co-administered adjuvant has on Trm differentiation is unclear. We show that while altering the adjuvant co-administered with the pulmonary delivered antigen does not impact the size of the lung Trm population, a particular ..View full abstract
We thank Dr. D. Jackson (Melbourne University, Australia) for TLR2 KO mice and Dr. S. Turner (Monash University, Australia) for influenza viruses (X31 and PR8). This work was supported by National Health and Medical Research Council of Australia to L.M.W.