Intravenous amino acid therapy for kidney protection in cardiac surgery patients: A pilot randomized controlled trial
Hong Pu, Gordon S Doig, Philippa T Heighes, Matilde J Allingstrup, Andy Wang, John Brereton, Carol Pollock, Douglas Chesher, Rinaldo Bellomo
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | MOSBY-ELSEVIER | Published : 2019
OBJECTIVE: To determine whether a continuous intravenous infusion of standard amino acids could preserve kidney function after on-pump cardiac surgery. METHODS: Adult patients scheduled to receive cardiac surgery lasting longer than 1 hour on-pump were randomized to standard care (n = 36) or an infusion of amino acids initiated immediately after induction of anesthesia (n = 33). The study's primary outcome measurements assessed renal function. These assessments included duration of renal dysfunction, duration and severity of acute kidney injury (AKI), estimated glomerular filtration rate (eGFR) over time, urine output, and use of renal-replacement therapy. Complications and other measures of..View full abstract
Awarded by Heart Research Australia
Dr Pu's Visiting Fellowship with the University of Sydney's Northern Clinical School Intensive Care Research Unit was enabled by a grant from the National Leading Clinical Specialty Foundation of the Department of Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Peoples Republic of China. This work was supported by peerreviewed academic grants from the Heart Research Australia (formerly North Shore Heart Research Foundation) Grant Number 2012-01 and the University of Sydney's Cardiothoracic Research Scheme. Baxter Healthcare Pty, Ltd, supplied the study amino acids.