Journal article

Acute opioid withdrawal following administration of oral oxycodone–naloxone due to portosystemic shunts

AR Peterson, P Aminian, PC Hey, P Gow

Journal of Pharmacy Practice and Research | Published : 2019


Background: The management of pain in patients with advanced liver disease is a clinical challenge. Initial pharmacokinetic safety data advised against the use of oxycodone–naloxone in this population, but in clinical practice it is commonly used. Our case aims to illustrate a potential mechanism by which administration of oxycodone–naloxone can cause systemic opioid antagonism and harm to patients. Clinical details: A 45-year-old man received two separate doses of oxycodone–naloxone in the immediate postoperative setting, resulting in symptoms and signs consistent with acute opioid withdrawal. A review of his imaging revealed significant portosystemic shunts. Outcomes: Portosystemic shunts ..

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University of Melbourne Researchers

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