Journal article

Difference in ability for extracellular Zn2 influx between human and rat amyloid beta(1-42) and its significance

Haruna Tamano, Hiroki Suzuki, Shuhei Kobuchi, Paul A Adlard, Ashley I Bush, Atsushi Takeda

NEUROTOXICOLOGY | ELSEVIER SCIENCE BV | Published : 2019

Abstract

The accumulation of amyloid-β1-42 (Aβ1-42), a constituively-generated peptide, in the brain is considered an upstream event in pathogenesis of Alzheimer's disease. Aβ1-42-induced pathophysiology has been extensively studied in experimental mice and rats. However, neurotoxicity of murine Aβ1-42 is much less understood than human Aβ1-42. Here we report difference in ability for extracellular Zn2+ influx into dentate granule cells of rats between human and rat Aβ1-42 and its significance. Human Aβ1-42 rapidly increased intracellular Zn2+, which was determined with intracellular ZnAF-2, in dentate granule cells, 5 min after injection of Aβ1-42 (25 μM, 1 μl) into the dentate gyrus, while rat Aβ1-..

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