Journal article

Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users

Richard W Foltin, Suzette M Evans, Margaret Haney, Kenneth Carpenter, Gillinder Bedi

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019

Abstract

Risky decision-making is characteristic of drug users, but little is known about the effects of circumstances, such as abstinence, on risky choice behavior in human drug users. We hypothesized that cocaine users would make more risky choices for cocaine (defined as taking a chance to receive a large number of cocaine doses as opposed to choosing to receive a fixed amount of cocaine) after 3 or 7 days of cocaine abstinence, compared to 1 day of cocaine abstinence. Six male nontreatment-seeking current cocaine smokers were enrolled in a 21-day inpatient within-subject study. Participants repeatedly smoked six 25 mg doses of cocaine during a training session and were instructed that they would ..

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University of Melbourne Researchers

Grants

Awarded by National Institute on Drug Abuse


Awarded by Columbia University's CTSA from NCATS-NCRR/NIH


Funding Acknowledgements

This research was supported by DA-021319 and KO5 DA031749 from the National Institute on Drug Abuse and approved by the New York State Psychiatric Institute Internal Review Board. The inpatient research unit was supported by Columbia University's CTSA grant No. UL1 RR024156 from NCATS-NCRR/NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The expert assistance of Alicia Couraud R.N. Jolie Gorchov, and Eric Rubin, M.D. is gratefully acknowledged.