Targeted Therapy against Metastatic Melanoma Based on Self-Assembled Metal-Phenolic Nanocomplexes Comprised of Green Tea Catechin
Ke Li, Gao Xiao, Joseph J Richardson, Blaise L Tardy, Hirotaka Ejima, Wen Huang, Junling Guo, Xuepin Liao, Bi Shi
Advanced Science | WILEY | Published : 2019
The targeted therapy of metastatic melanoma is an important yet challenging goal that has received only limited attention to date. Herein, green tea polyphenols, (–)‐epigallocatechin‐3‐gallate (EGCG), and lanthanide metal ions (Sm3+) are used as building blocks to engineer self‐assembled SmIII‐EGCG nanocomplexes with synergistically enhanced tumor inhibitory properties. These nanocomplexes have negligible systemic toxic effects on healthy cells but cause a significant reduction in the viability of melanoma cells by efficiently regulating their metabolic pathways. Moreover, the wound‐induced migration of melanoma cells can be efficiently inhibited by SmIII‐EGCG, which is a key criterion for m..View full abstract
Awarded by National Science and Technology Major Project
Awarded by National Natural Science Foundation of China
Awarded by Japan Society for the Promotion of Science (JSPS)
This work was supported by the National Science and Technology Major Project (Grant No. 2017YFB0308500), National Natural Science Foundation of China (Grant No. 21506036), and National Double First-Rate Project. J.J.R. acknowledges Japan Society for the Promotion of Science (JSPS) funding project (ID PE17019). The authors acknowledge Yana Klyachina for helpful discussions. All experimental animals were treated according to the protocols approved by the Bioethics Committee of West China Center of Medical Sciences, Sichuan University.