High fat diet and associated changes in the expression of micro-RNAS in tissue: Lessons learned from animal studies
Robin A Wilson, William Deasy, Alan Hayes, Matthew B Cooke
MOLECULAR NUTRITION & FOOD RESEARCH | WILEY | Published : 2017
Environment and genetic factors play an important role in the development of obesity, and diet is one of the main contributing factors to this disease. High fat intake is associated with body weight gain, leading to obesity and other metabolic diseases. MicroRNAs (miRNAs) are a group of small, noncoding RNAs that are important regulators of gene expression at posttranscriptional level. Studies have shown that high fat intake, independent of body weight status, can significantly impact both negatively and positively the expression of miRNAs and thus the biological function of tissues such as adipose, skeletal, and cardiac muscle, liver, neuronal, and endothelial. This review will summarize th..View full abstract
R.W. is supported by Victoria University International Postgraduate research Scholarship. The authors would like to thank all of the animals, graduate students, and researchers that have contributed to the body of research cited in this comprehensive review.