Journal article
Attenuation of resting but not load-mediated protein synthesis in prostate cancer patients on androgen deprivation
ED Hanson, AR Nelson, DWD West, JA Violet, L O'Keefe, SM Phillips, A Hayes
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2017
DOI: 10.1210/jc.2016-3383
Abstract
Context: Androgen deprivation therapy (ADT) is a common prostate cancer (PCA) treatment but results in muscular atrophy. Periodic increases in muscle protein synthesis (MPS) that occur after resistance exercise or protein intake may ameliorate this muscle loss, but the impact of these anabolic stimuli during ADT is unclear. Objective: To determine the acute MPS response to whey protein supplementation with and without resistance exercise during ADT. Design: Acute response in PCA patients vs age-matched controls (CON). Setting: Academic laboratory setting. Participants: PCA patients on ADT (N = 8) and CON (N = 10). Intervention: A standardized diet was consumed for 2 days prior to performing ..
View full abstractGrants
Awarded by National Science and Engineering Research Council of Canada
Funding Acknowledgements
This work was supported by funding from the following sources: E.D.H. was supported by a research development grant scheme from Victoria University and the Oded Bar-Or International Scholar Award from the American College of Sports Medicine. D.W.D.W. was supported by a Canadian Institutes for Health Research doctoral award. S.M.P. was supported by grants from the National Science and Engineering Research Council of Canada (RGPIN-04613), the Canadian Institutes for Health Research, and the Canada Research Chairs Program. A.H. was supported by Collaborative Research Network funding from the Department of Industry, Innovation and Science of Australia.