Frontline treatment of epithelial ovarian cancer.
Jeffrey Goh, G Raj Mohan, Rahul Ladwa, Sumitra Ananda, Paul A Cohen, Sally Baron-Hay
Asia Pac J Clin Oncol | Published : 2015
This is a contemporaneous review of the frontline treatment of epithelial ovarian cancer (EOC), specifically on the importance of optimal surgical cytoreductive surgery, the pivotal role of platinum-based adjuvant chemotherapy (which encompasses intraperitoneal and dose-dense regimens) and the emergence of neo-adjuvant chemotherapy. Additionally, the benefit of concurrent and maintenance bevacizumab in the suboptimally debullked stage III and stage IV EOC setting is also reviewed. The article also discusses the increasing importance of prognostic and predictive molecular biomarkers in the future management of EOC.