Association between drug-eluting stent type and clinical outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention

W Chan; J Ivanov; MA Kotowycz; M Sibbald; R McGeoch; N Crooks; R Hatton; D Ing; P Daly; K Mackie; MD Osten; PH Seidelin; A Barolet; CB Overgaard; V Džavík

Journal article

Association between drug-eluting stent type and clinical outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention

W Chan, J Ivanov, MA Kotowycz, M Sibbald, R McGeoch, N Crooks, R Hatton, D Ing, P Daly, K Mackie, MD Osten, PH Seidelin, A Barolet, CB Overgaard, V Džavík

Canadian Journal of Cardiology | Published : 2014

DOI: 10.1016/j.cjca.2014.04.034

Abstract

Background: The comparative efficacy of first- vs second-generation drug-eluting stents (DESs) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) is unknown. Methods: A retrospective analysis of consecutive patients undergoing PCI at a tertiary PCI center from 2007-2011 was performed, with linkage to administrative databases for long-term outcomes. CKD was defined as creatinine clearance (CrCl) < 60 mL/min. Propensity matching by multivariable scoring method and Kaplan-Meier analyses were performed. Results: Of 6481 patients with available CrCl values undergoing a first PCI during the study period, 1658 (25%) had CKD. First- and second-generatio..

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