Association between drug-eluting stent type and clinical outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention.
William Chan, Joan Ivanov, Mark A Kotowycz, Matthew Sibbald, Ross McGeoch, Noel Crooks, Rachael Hatton, Douglas Ing, Paul Daly, Karen Mackie, Mark D Osten, Peter H Seidelin, Alan Barolet, Christopher B Overgaard, Vladimír Džavík
Can J Cardiol | Published : 2014
BACKGROUND: The comparative efficacy of first- vs second-generation drug-eluting stents (DESs) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) is unknown. METHODS: A retrospective analysis of consecutive patients undergoing PCI at a tertiary PCI center from 2007-2011 was performed, with linkage to administrative databases for long-term outcomes. CKD was defined as creatinine clearance (CrCl) < 60 mL/min. Propensity matching by multivariable scoring method and Kaplan-Meier analyses were performed. RESULTS: Of 6481 patients with available CrCl values undergoing a first PCI during the study period, 1658 (25%) had CKD. First- and second-generatio..View full abstract