Journal article

Management of the no-reflow phenomenon.

Michelle J Butler, William Chan, Andrew J Taylor, Anthony M Dart, Stephen J Duffy

Pharmacol Ther | Published : 2011


The lack of reperfusion of myocardium after prolonged ischaemia that may occur despite opening of the infarct-related artery is termed "no reflow". No reflow or slow flow occurs in 3-4% of all percutaneous coronary interventions, and is most common after emergency revascularization for acute myocardial infarction. In this setting no reflow is reported to occur in 30% to 40% of interventions when defined by myocardial perfusion techniques such as myocardial contrast echocardiography. No reflow is clinically important as it is independently associated with increased occurrence of malignant arrhythmias, cardiac failure, as well as in-hospital and long-term mortality. Previously the no-reflow ph..

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University of Melbourne Researchers