Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot; Marion Herisse; Liam Sharkey; Liselle Atkin; Jessica L Porter; Torsten Seemann; Benjamin P Howden; Mark A Rizzacasa; Timothy P Stinear

Journal article

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2019

DOI: 10.1002/anie.201900290

University of Melbourne Researchers

Torsten Seemann Author Microbiology and Immunology

Ben Howden Author Microbiology and Immunology

Jessica Porter Author Microbiology and Immunology

Marion Herisse Author Microbiology and Immunology

Mark Rizzacasa Author Chemistry

Related Projects (1)

NEW ANTBIOTICS FROM OLD MICROBES

Once treatable infections are becoming deadly because bacteria are developing broad antibiotic resistance. New medicines are urgently needed..

Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

We wish to thank Ching-Seng Ang, Shuai Nai, and Nick Williamson at the Bio21 Mass Spectrometry and Proteomics Facility for helpful discussions and assistance with mass spectrometry. This work was supported by an Australian National Health and Medical Research Council grant GNT1105522.