Journal article

Mycoplasmas under experimental antimicrobial selection: The unpredicted contribution of horizontal chromosomal transfer

Marion Faucher, Laurent-Xavier Nouvel, Emilie Dordet-Frisoni, Eveline Sagne, Eric Baranowski, Marie-Claude Hygonenq, Marc-Serge Marenda, Florence Tardy, Christine Citti



Horizontal Gene Transfer was long thought to be marginal in Mycoplasma a large group of wall-less bacteria often portrayed as minimal cells because of their reduced genomes (ca. 0.5 to 2.0 Mb) and their limited metabolic pathways. This view was recently challenged by the discovery of conjugative exchanges of large chromosomal fragments that equally affected all parts of the chromosome via an unconventional mechanism, so that the whole mycoplasma genome is potentially mobile. By combining next generation sequencing to classical mating and evolutionary experiments, the current study further explored the contribution and impact of this phenomenon on mycoplasma evolution and adaptation using the..

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University of Melbourne Researchers


Funding Acknowledgements

This work was supported by National Institute for Agricultural Research (INRA;, National Veterinary School of Toulouse (ENVT; and French Agency for Food, Environmental and Occupational Health & Safety (ANSES; funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.