Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms
Ye Tian, Andrew Zalesky, Chad Bousman, Ian Everall, Christos Pantelis
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING | ELSEVIER | Published : 2019
BACKGROUND: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigate whether the diversity in functional connectivity across the insula's topography is altered in individuals with schizophrenia and relates to the clinical symptoms of the disorder. METHODS: Insula-to-whole-brain functional connectivity was mapped using resting-state functional magnetic resonance imaging at the resolution of voxels in individuals with schizophrenia (n = 49) and healthy comparison individuals (n = 52). Diversity in functional connectivity across the insula's topography was represented as discrete subregions and gradients of continuous variation. Can..View full abstract
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Awarded by Australian National Health and Medical Research Council
This work was supported by the China Scholarship Council-University of Melbourne Research Scholarship (to YT), Australian National Health and Medical Research Council Senior Research Fellowship B (Grant No. 1136649 [to AZ]), and Australian National Health and Medical Research Council Senior Principal Research Fellowship (Grant Nos. 628386 and 1105825 [to CP]).