Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Y Tian; A Zalesky; C Bousman; I Everall; C Pantelis

Journal article

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Y Tian, A Zalesky, C Bousman, I Everall, C Pantelis

Biological Psychiatry Cognitive Neuroscience and Neuroimaging | ELSEVIER | Published : 2019

DOI: 10.1016/j.bpsc.2018.12.003

Abstract

Background: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigate whether the diversity in functional connectivity across the insula's topography is altered in individuals with schizophrenia and relates to the clinical symptoms of the disorder. Methods: Insula-to-whole-brain functional connectivity was mapped using resting-state functional magnetic resonance imaging at the resolution of voxels in individuals with schizophrenia (n = 49) and healthy comparison individuals (n = 52). Diversity in functional connectivity across the insula's topography was represented as discrete subregions and gradients of continuous variation. Can..

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University of Melbourne Researchers

Ye Ella Tian Author

Andrew Zalesky Author

Christos Pantelis Author

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Grants

Awarded by Eli Lilly and Company

Funding Acknowledgements

This work was supported by the China Scholarship Council-University of Melbourne Research Scholarship (to YT), Australian National Health and Medical Research Council Senior Research Fellowship B (Grant No. 1136649 [to AZ]), and Australian National Health and Medical Research Council Senior Principal Research Fellowship (Grant Nos. 628386 and 1105825 [to CP]).