Journal article

Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women

Cassandra Szoeke, Alicia M Goodwill, Alexandra Gorelik, Lorraine Dennerstein, Karen Caeyenberghs, Steven Simpson, Edward Hill, Stephen Campbell

JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2019

Abstract

Cerebral amyloid-β (Aβ) plaques are the hallmark biomarker of Alzheimer's disease (AD) and are detectable decades before clinical symptoms. Modifying risk factors associated with Aβ accrual offers an opportunity for AD prevention. While midlife vascular health is linked to AD; there is minimal longitudinal evidence regarding the effect of midlife lipids on Aβ. We examined the association between midlife lipids and Aβ 20 years later. One hundred and twenty-two women had serum lipid profiles in midlife (1992, 45-57 years), and cerebral imaging, genotyping, and cognition measured 20 years later (2012/13, 66-77 years). Imaging was performed in 2012/13 via F-18 Florbetaben positron emission tomog..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Alzheimer's Association


Funding Acknowledgements

Funding for the Healthy Ageing Program (HAP) has been provided by the National Health and Medical Research Council (NHMRC Grants 547600, 1032350 & 1062133), Ramaciotti Foundation, Australian Healthy Ageing Organisation, the Brain Foundation, the Alzheimer's Association (NIA320312), Australian Menopausal Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation and Alzheimer's Australia. Inaugural funding was provided by VicHealth and the NHMRC. The Principal Investigator of HAP (CSz) is supported by the National Health and Medical Research Council. EH is supported by an Australian Government Research Training Program Scholarship.