Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study

VL Villemagne; D Velakoulis; V Doré; S Bozinoski; CL Masters; CC Rowe; M Walterfang

Journal article

Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study

VL Villemagne, D Velakoulis, V Doré, S Bozinoski, CL Masters, CC Rowe, M Walterfang

European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2019

DOI: 10.1007/s00259-019-4273-7

Abstract

Purpose: Niemann-Pick type C (NPC) is a cholesterol storage disease characterized by disruption in the endosomal–lysosomal transport system that leads to the accumulation of cholesterol and glycolipids in lysosomes. Developmental cognitive delay and progressive motor and cognitive impairment are characteristic of the disease. Tau accumulation has been reported in some NPC patients. We investigated the presence of tau and Aβ-amyloid deposits in a group of NPC patients and for comparison in age-matched healthy controls (HC). Methods: Eight NPC patients and seven HC were included in the study. Participants underwent tau imaging with 18 F-AV1451 and amyloid imaging with 11 C-PiB. Both 18 F-AV145..

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University of Melbourne Researchers

Victor Villemagne Author

Dennis Velakoulis Author

Christopher Rowe Author

Mark Walterfang Author

Grants

Funding Acknowledgements

This work was supported in part by the Austin Hospital Medical Research Foundation. The funding source was not involved in the study design, in the collection, analysis and interpretation of the data, in the writing of the report, or in the decision to submit the paper for publication.