A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers; Victoria W Wen; Shiloh MC Middlemiss; Brenna Osborne; Helen Forgham; MoonSun Jung; Mawar Karsa; Molly Clifton; Angelika Bongers; Jixuan Gao; Chelsea Mayoh; Newsha Raoufi-Rad; Eric P Kusnadi; Kate M Hannan; David A Scott; Alan Kwek; Bing Liu; Claudia Flemming; Daria A Chudakova; Ruby Pandher; Tim W Failes; James Lim; Andrea Angeli; Andrei L Osterman; Toshihiko Imamura; Ursula R Kees; Claudiu T Supuran; Richard B Pearson; Ross D Hannan; Thomas P Davis; Joshua McCarroll; Maria Kavallaris; Nigel Turner; Andrei V Gudkov; Michelle Haber; Murray D Norris; Michelle J Henderson

Journal article

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers, Victoria W Wen, Shiloh MC Middlemiss, Brenna Osborne, Helen Forgham, MoonSun Jung, Mawar Karsa, Molly Clifton, Angelika Bongers, Jixuan Gao, Chelsea Mayoh, Newsha Raoufi-Rad, Eric P Kusnadi, Kate M Hannan, David A Scott, Alan Kwek, Bing Liu, Claudia Flemming, Daria A Chudakova, Ruby Pandher Show all

Oncogene | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41388-018-0666-5

University of Melbourne Researchers

Eric Kusnadi Author The Sir Peter MacCallum Department of Oncology

Richard Pearson Author The Sir Peter MacCallum Department of Oncology

Katherine Hannan Author Biochemistry and Molecular Biology

Ross Hannan Author The Sir Peter MacCallum Department of Oncology

Grants

Awarded by NCI Cancer Center Support Grant

Funding Acknowledgements

This research was supported by NHMRC, Leukemia Foundation, Anthony Rothe Memorial Trust, NSW Cancer Council, Cancer Institute NSW, Tenix Foundation, ISG Foundation and the Children's Leukemia & Cancer Research Foundation, Perth. Metabolic analysis was performed at the Cancer Metabolism Core, SBP Medical Discovery Institute, with assistance from Olga Zagnitko and support of NCI Cancer Center Support Grant P30 CA30199.