Journal article

Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D Young, Pasi K Korhonen, Geoffrey N Gobert, Sujeevi Nawaratna, Shihab Hasan, David M Martinez, Hong You, Martin Lavin, Malcolm K Jones, Mark A Ragan, Jens Stoye, Ana Oleaga, Aidan M Emery, Bonnie Webster, David Rollinson, Robin B Gasser, Donald P McManus Show all

PLOS Pathogens | Public Library of Science (PLoS) | Published : 2019

Abstract

Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite S. haematobium with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the S. bovis genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of S. bovis and S. haematobium ap..

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Grants

Awarded by NHMRC SPRF


Awarded by NHMRC


Funding Acknowledgements

This work was supported by grants from the QIMR Berghofer Medical Research Institute (Chenhall Estate) and the Australian Infectious Diseases Research Centre. NDY was supported by a National Health and Medical Research Council (NHMRC) CDF1, PKK by an NHMRC ECRF and DPM by an NHMRC SPRF (APP1102926). The work has been supported by NHMRC project grant APP1102322. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.