Journal article

Outer Membrane Vesicle-Host Cell Interactions

Jessica D Cecil, Natalie Sirisaengtaksin, Neil M O'Brien-Simpson, Anne Marie Krachler

Microbiology Spectrum | AMER SOC MICROBIOLOGY | Published : 2019

Abstract

Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range of chemically diverse cargoes, including lipids and lipopolysaccharides, membrane-embedded and associated proteins and small molecules, peptidoglycan, and nucleic acids. Particularly, virulence factors such as adhesins and toxins are often enriched in OMVs. Here we discuss a variety of ways in which OMVs facilitate host-microbe interactions, including their contributions to biofilm formation, nutr..

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Grants

Awarded by NIH


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

Our research is funded by a UTSystems STAR award and the NIH (grant R01 AI132354) and by the Australian Government, Department of Industry, Innovation and Science, the Australian Dental Research Foundation (ADRF), and National Health and Medical Research Council (NHMRC) project grant APP1101935.