Journal article

The long and the short of it: the MDM4 tail so far

Sue Haupt, Javier Octavio Mejia-Hernandez, Reshma Vijayakumaran, Simon P Keam, Ygal Haupt

JOURNAL OF MOLECULAR CELL BIOLOGY | OXFORD UNIV PRESS | Published : 2019

Abstract

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilitates MDM2's E3 ligase activity toward p53. These functions of MDM4 are critical for normal cell function and a proper response to stress. Their importance for proper cell maintenance and proliferation identifies them as a risk for deregulation associated with the uncontrolled growth of cancer. MDM4 tails are vital for its function, where its N-terminus transactivation domain eng..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

The work in the author's lab is supported by grants from National Health and Medical Research Council (NHMRC 1123057), Sister Institute Network Fund (SINF), and the Peter MacCallum Cancer Foundation. J.O.M.H. is supported by Melbourne Research Scholarship from The University of Melbourne. R.V. is supported by the Victoria-India Doctoral Scholarship (VIDS) and the Melbourne International Fee Remission Scholarship (MIFRS).