Journal article

A simple technique for development of fibres with programmable microsphere concentration gradients for local protein delivery

Fahimeh Mehrpouya, Zhilian Yue, Tony Romeo, Robert Gorkin, Robert MI Kapsa, Simon E Moulton, Gordon G Wallace

JOURNAL OF MATERIALS CHEMISTRY B | ROYAL SOC CHEMISTRY | Published : 2019

Abstract

Alginate has been a biologically viable option for controlled local delivery of bioactive molecules in vitro and in vivo. Specific bioactive molecule release profiles are achieved often by controlling polymer composition/concentration, which also determines the modulus of hydrogels. This largely limits alginate-mediated bioactive molecule delivery to single-factors of uniform concentration applications, rather than applications that may require (multiple) bioactive molecules delivered at a concentration gradient for chemotactic purposes. Here we report a two-phase PLGA/alginate delivery system composed of protein-laden poly-d,l-lactic-co-glycolic acid (PLGA) microspheres wet-spun into algina..

View full abstract

Grants

Awarded by Australian Research Council Centre of Excellence Scheme


Awarded by ARC under the Australian Laureate Fellowship scheme


Funding Acknowledgements

Funding from the Australian Research Council Centre of Excellence Scheme (Project Number CE 14100012) is gratefully acknowledged. Gordon G. Wallace is grateful to the ARC for support under the Australian Laureate Fellowship scheme (FL 110100196). The authors also gratefully acknowledge the use of facilities within the Electron Microscopy Centre (EMC) and the Australian National Fabrication Facility (ANFF). Finally, the authors thank Associate Professor Chee O. Too for proofreading this manuscript.