Journal article

Pigmented squamous cell carcinoma of the skin: morphologic and immunohistochemical study of five cases

MB Morgan, J Lima-Maribona, RA Miller, T Kilpatrick, M Tannenbaum

Journal of Cutaneous Pathology | WILEY | Published : 2000


Invasive pigmented squamous cell carcinoma (PSCC) of the skin is reportedly rare. Herein, we evaluate an additional five cases and compare their relative frequency with non-pigmented squamous cell carcinoma (SCC). Of 46,791 archived cases of SCC, a total of five cases of PSCC were discovered for a relative frequency of approximately 0.01%. Grossly, each tumor presented as a rapidly growing crusted papule on actinic damaged skin of the face. Microscopically, all were composed of a mixture of keratininized squamous cells and melanin-producing dendritic melanocytes. The squamous cells stained for epithelial membrane antigen, and both low and high molecular keratins. The melanocytes stained for ..

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