Comparison of Cocaine/Crack Biomarkers Concentrations in Oral Fluid, Urine and Plasma Simultaneously Collected From Drug Users
Tais Regina Fiorentin, Juliana Nichterwitz Scherer, Marcelo Caetano Alexandre Marcelo, Tanara Rosangela Vieira Sousa, Flavio Pechansky, Marco Flores Ferrao, Renata Pereira Limberger
JOURNAL OF ANALYTICAL TOXICOLOGY | OXFORD UNIV PRESS INC | Published : 2018
The use of oral fluid (OF) as an alternative specimen for drug analysis has become very popular in forensic toxicology. Many clinical studies have evaluated the correlations between concentrations of cocaine and its metabolites in OF and other matrices, but results have shown high variability. In addition, there are no data available regarding the correlations between biomarkers of crack-cocaine use in different matrices. This study evaluated the relationship between concentrations of cocaine/crack-cocaine biomarkers in OF, urine and plasma samples collected from cocaine users. All samples were analyzed for the presence of cocaine (COC), benzoylecgonine (BZE) and anhydroecgonine (AEC) by a v..View full abstract
This work was supported by the Brazilian National Secretariat on Drugs Policies (SENAD) and the Hospital de Clinicas de Porto Alegre Research Incentive Fund (FIPE-HCPA). TRF and JNS received grants from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES).