Journal article

Comparison of Cocaine/Crack Biomarkers Concentrations in Oral Fluid, Urine and Plasma Simultaneously Collected From Drug Users

Tais Regina Fiorentin, Juliana Nichterwitz Scherer, Marcelo Caetano Alexandre Marcelo, Tanara Rosangela Vieira Sousa, Flavio Pechansky, Marco Flores Ferrao, Renata Pereira Limberger

JOURNAL OF ANALYTICAL TOXICOLOGY | OXFORD UNIV PRESS INC | Published : 2018

Abstract

The use of oral fluid (OF) as an alternative specimen for drug analysis has become very popular in forensic toxicology. Many clinical studies have evaluated the correlations between concentrations of cocaine and its metabolites in OF and other matrices, but results have shown high variability. In addition, there are no data available regarding the correlations between biomarkers of crack-cocaine use in different matrices. This study evaluated the relationship between concentrations of cocaine/crack-cocaine biomarkers in OF, urine and plasma samples collected from cocaine users. All samples were analyzed for the presence of cocaine (COC), benzoylecgonine (BZE) and anhydroecgonine (AEC) by a v..

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