Journal article
Feeding induced by cannabinoids is mediated independently of the melanocortin system
P Sinnayah, EE Jobst, JA Rathner, AD Caldera-Siu, L Tonelli-Lemos, AJ Eusterbrock, PJ Enriori, EN Pothos, KL Grove, MA Cowley
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2008
Abstract
Background: Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss. Little is known about how CB1-R antagonists affect the central neurocicuitry, specifically the melanocortin system that regulates energy balance. Methodology/Principal Finding: Here, we show that peripherally administered CB1-R antagonist (AM251) or agonist equally suppressed or stimulated feeding respectively in Ay, which lack a functional melanocortin system, and wildtype mice, demonstrating that cannabinoid effects on feeding do no require melanocortin circuitry. CB1-R antagonist or agonist administered into the ventral..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
This work was supported by grants from the National Institutes of Health (RR0163, DK62202 and DK60685). The work in the Pothos laboratory was supported by DK065872, P30 NS047243 (Tufts Center for Neuroscience Research), P30 DK34928 (Tufts GRASP Center) and a Smith Family New Investigator Award through the Medical Foundation. OHSU and Dr. Cowley have a significant financial interest in Orexigen Therapeutics Inc., a company that may have a commercial interest in the results of this research and technology. This potential conflict has been reviewed and managed by the OHSU Conflict of Interest in Research Committee and the Integrity Program Oversight Council.