Journal article

Feeding Induced by Cannabinoids Is Mediated Independently of the Melanocortin System

Puspha Sinnayah, Erin E Jobst, Joseph A Rathner, Angela D Caldera-Siu, Luciana Tonelli-Lemos, Aaron J Eusterbrock, Pablo J Enriori, Emmanuel N Pothos, Kevin L Grove, Michael A Cowley

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008

Abstract

BACKGROUND: Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss. Little is known about how CB1-R antagonists affect the central neurocircuitry, specifically the melanocortin system that regulates energy balance. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that peripherally administered CB1-R antagonist (AM251) or agonist equally suppressed or stimulated feeding respectively in A(y) , which lack a functional melanocortin system, and wildtype mice, demonstrating that cannabinoid effects on feeding do not require melanocortin circuitry. CB1-R antagonist or agonist administered into the v..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by Tufts Center for Neuroscience Research


Awarded by Tufts GRASP Center


Awarded by Medical Foundation


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This work was supported by grants from the National Institutes of Health (RR0163, DK62202 and DK60685). The work in the Pothos laboratory was supported by DK065872, P30 NS047243 (Tufts Center for Neuroscience Research), P30 DK34928 (Tufts GRASP Center) and a Smith Family New Investigator Award through the Medical Foundation. OHSU and Dr. Cowley have a significant financial interest in Orexigen Therapeutics Inc., a company that may have a commercial interest in the results of this research and technology. This potential conflict has been reviewed and managed by the OHSU Conflict of Interest in Research Committee and the Integrity Program Oversight Council.