Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin- related kinase receptor-B signaling
Andrew Osborne, Tasneem Z Khatib, Lalana Songra, Amanda C Barber, Katie Hall, George YX Kong, Peter S Widdowson, Keith R Martin
Cell Death and Disease | NATURE PUBLISHING GROUP | Published : 2018
The authors acknowledge a Wellcome Trust Pathfinder Award which partially supported this work. Special thanks to Susan Wilson (Histochemistry Research Unit, Southampton General Hospital) and Robert Adalbert (John van Geest Centre for Brain Repair, University of Cambridge) for assistance with optic nerve sectioning and processing. Thank you also to Nicolas Belforte (Department of Neurosciences, University of Montreal) for advice on quantifying fluorescence within individual RGCs. This work was supported by, the Midven Rainbow Seed Fund, Quethera Ltd, University of Cambridge Enterprise, the HB Allen Charitable Trust, and the Cambridge Eye Trust.