Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work
Adam J Trewin, Lewan Parker, Christopher S Shaw, Danielle S Hiam, Andrew Garnham, Itamar Levinger, Glenn K McConell, Nigel K Stepto
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2018
It remains unclear whether high-intensity interval exercise (HIIE) elicits distinct molecular responses to traditional endurance exercise relative to the total work performed. We aimed to investigate the influence of exercise intensity on acute perturbations to skeletal muscle mitochondrial function (respiration and reactive oxygen species) and metabolic and redox signaling responses. In a randomized, repeated measures crossover design, eight recreationally active individuals (24 ± 5 yr; V̇o2peak: 48 ± 11 ml·kg-1·min-1) undertook continuous moderate-intensity [CMIE: 30 min, 50% peak power output (PPO)], high-intensity interval (HIIE: 5 × 4 min, 75% PPO, work matched to CMIE), and low-volume ..View full abstract
Awarded by Future Leader Fellowship from the National Heart Foundation of Australia
N. K. Stepto was supported by the Australian Governments Collaborative Research Network. I. Levinger was supported by Future Leader Fellowship (ID: 100040) from the National Heart Foundation of Australia.