Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle
Adam J Trewin, Leonidas S Lundell, Ben D Perry, Kim Vikhe Patil, Alexander V Chibalin, Itamar Levinger, Leon R McQuade, Nigel K Stepto
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | AMER PHYSIOLOGICAL SOC | Published : 2015
-Reactive oxygen species (ROS) produced in skeletal muscle may play a role in potentiating the beneficial responses to exercise; however, the effects of exercise-induced ROS on insulin action and protein signaling in humans has not been fully elucidated. Seven healthy, recreationally active participants volunteered for this double-blind, randomized, repeated-measures crossover study. Exercise was undertaken with infusion of saline (CON) or the antioxidant N-acetylcysteine (NAC) to attenuate ROS. Participants performed two 1-h cycling exercise sessions 7-14 days apart, 55 min at 65% V̇o2peak plus 5 min at 85%V̇o2peak, followed 3 h later by a 2-h hyperinsulinemic euglycemic clamp (40 mIU·min(-..View full abstract
Awarded by Novo Nordisk Fonden
This study was funded by the Victoria University Research Development Grant Scheme, the Swedish Research Council, the Novo Nordisk Foundation, and the Strategic Research Program in Diabetes. I. Levinger is a Heart Foundation Future Leader Fellow (ID No. 100040). N. K. Stepto was supported by the Australian Government Collaborative Research Network Grant Scheme.