Journal article

Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes

James R Fernando, Peiyan Shen, Christina PC Sim, Yu-Yen Chen, Glenn D Walker, Yi Yuan, Coralie Reynolds, David P Stanton, Colin M MacRae, Eric C Reynolds

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Dental caries, erosion and hypersensitivity are major public health problems. SnF2 is used widely in oral care products to help prevent/treat these conditions. Casein phosphopeptide-stabilised amorphous calcium phosphate nanocomplexes (CPP-ACP) are a biomimetic nanotechnology of salivary phosphopeptide-ACP complexes that deliver bioavailable calcium and phosphate ions to promote dental remineralisation (repair). We show here using in vitro studies and a double-blind, randomised controlled, cross-over design in situ clinical trial that SnF2 and CPP-ACP interact to form a nanofilament coating on the tooth surface and that together they are superior in their ability to promote dental reminerali..

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