Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes
James R Fernando, Peiyan Shen, Christina PC Sim, Yu-Yen Chen, Glenn D Walker, Yi Yuan, Coralie Reynolds, David P Stanton, Colin M MacRae, Eric C Reynolds
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019
Dental caries, erosion and hypersensitivity are major public health problems. SnF2 is used widely in oral care products to help prevent/treat these conditions. Casein phosphopeptide-stabilised amorphous calcium phosphate nanocomplexes (CPP-ACP) are a biomimetic nanotechnology of salivary phosphopeptide-ACP complexes that deliver bioavailable calcium and phosphate ions to promote dental remineralisation (repair). We show here using in vitro studies and a double-blind, randomised controlled, cross-over design in situ clinical trial that SnF2 and CPP-ACP interact to form a nanofilament coating on the tooth surface and that together they are superior in their ability to promote dental reminerali..View full abstract
Awarded by Australian Government Department of Industry, Innovation and Science
This study was supported by the Australian Government Department of Industry, Innovation and Science grant 20080108.