Synthesis, characterization, theoretical and cytotoxicity studies of Pd(II) and Pt(II) complexes with new bidentate carbon donor ligand

Abstract

The new phosphonium salt, the C,C-chelating phosphorus ylide ligand, (MeOC6H5C(O)CH[dbnd]PPh2(CH2)2PPh2[dbnd]CHC(O)C6H5OMe), and its Pd(II) and Pt(II) complexes have been synthesized and the cytotoxic activity of the synthesized complexes against three human cancer cell lines, including HeLa (Human cervix cancer cell line), KB (human oral cancer cell line) and U87 MG (human glioblastoma cell line) were evaluated using an MTT assay. The new compounds were identified and characterized using multinuclear (1H, 13C and 31P) NMR, infrared (IR) spectroscopy, elemental analysis, and through UV absorption and fluorescence emission spectra. Also, the crystal structure of the phosphorus ylide ligand wa..