Journal article

Partitioning the roles of insect and microbial enzymes in the metabolism of the insecticide imidacloprid in Drosophila melanogaster

Roberto Fusetto, Shane Denecke, Trent Perry, Richard O’Hair, Philip Batterham

Published : 2017


Resistance to insecticides through enhanced metabolism is a worldwide problem. The Cyp6g1 gene of the vinegar fly, Drosophila melanogaster , is a paradigm for the study of metabolic resistance. Constitutive overexpression of this gene confers resistance to several chemical classes of insecticides, including the neonicotinoids exemplified by the insecticide imidacloprid (IMI). The metabolism of IMI in this species has been previously shown to yield oxidative and nitro-reduced metabolites. While levels of the oxidative metabolites are correlated with CYP6G1 expression, nitro-reduced metabolites are not, raising the question of how these metabolites are produced. Some IMI metabolites are known ..

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