Journal article

Klotho allele status is not associated with A beta and APOE epsilon 4-related cognitive decline in preclinical Alzheimer's disease

Tenielle Porter, Samantha C Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Yen Ying Lim, David Ames, Colin L Masters, Ralph N Martins, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws



The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS ..

View full abstract


Awarded by Dementia Collaborative Research Centres program

Awarded by Cooperative Research Centre (CRC) for Mental Health through CRC Program, an Australian Government Initiative

Funding Acknowledgements

The authors thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. The authors kindly thank all AIBL Research Group members ( Funding for the AIBL study was provided in part by the study partners [Commonwealth Scientific and Industrial Research Organisation, Australia, Edith Cowan University, Australia, Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd]. The AIBL study has also received support from the National Health and Medical Research Council, Australia and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund, Australia and the Cooperative Research Centre (CRC) for Mental Health-funded through the CRC Program (Grant ID: 20100104), an Australian Government Initiative.