Journal article

Bone Turnover Markers in Men and Women with Impaired Fasting Glucose and Diabetes

Kara L Holloway-Kew, Lelia LF De Abreu, Mark A Kotowicz, Muhammad A Sajjad, Julie A Pasco

CALCIFIED TISSUE INTERNATIONAL | SPRINGER | Published : 2019

Abstract

Bone turnover markers (BTMs) are reduced in diabetes, but whether BTM changes occur in impaired fasting glucose (IFG) is unknown. The aim of this study was to investigate whether BTMs are altered in IFG and diabetes compared to normoglycaemia. For men and women (n = 2222) in the Geelong Osteoporosis Study, IFG was defined as fasting plasma glucose (FPG) 5.5-6.9 mmol/L and diabetes as FPG ≥ 7.0 mmol/L, use of antihyperglycemic medication and/or self-report. Serum C-terminal telopeptide (CTx) and procollagen type 1 N-terminal propeptide (P1NP) were measured. After natural log transformation to normalise the data, multivariable regression was used to examine the relationship between glycaemia s..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Funding Acknowledgements

The Geelong Osteoporosis Study was supported by the Victorian Health Promotion Foundation, National Health and Medical Research Council (NHMRC), Australia (Projects 251638 and 628582) and the Geelong Regional Medical Foundation; however, the funding bodies played no part in either the design or conduct of the study, the collection, management, analysis, and interpretation of the data or the preparation or review of the paper. LFFA and MAS are supported by Postgraduate Scholarships from Deakin University and KLH-K is supported by an Alfred Deakin Postdoctoral Research Fellowship. LLFA, KLH-K, MAS, MAK and JAP have no other conflict of interest to declare.